School of Medicine: Recent submissions
Now showing items 461-480 of 567
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Genetic analysis of HIV-1 subtypes in Nairobi, Kenya
(Public Library of Science, 2008-09-11)Genetic analysis of a viral infection helps in following its spread in a given population, in tracking the routes of infection and, where applicable, in vaccine design. Additionally, sequence analysis of the viral genome ... -
Macro CK in patients with elevated troponin I levels: case report: online article
(Clinics Cardive Publishing, 2012-02-01)CK-MB activity levels can be falsely elevated by the presence of macro CK, especially if immuno-inhibition assays are used in the measurement. In patients with macro CK and cardiac pathology that could result in an elevated ... -
Population-specific evolution of HIV Gag epitopes in genetically diverged patients
(Elsevier, 2013-06-01)Under the host selection pressure HIV evolves rapidly to override crucial steps in the antigen presentation pathway. This allows the virus to escape binding and recognition by cytotoxic T lymphocytes. Selection pressures ... -
HIV-1 progression links with viral genetic variability and subtype, and patient’s HLA type: analysis of a Nairobi-Kenyan cohort
(Springer Berlin Heidelberg, 2014-02-01)In a Nairobi-Kenyan cohort of 50 HIV-1 positive patients, we analysed the prevalence of HIV-1 subtypes and human leucocyte antigen (HLA) alleles. From this cohort, 33 patients were selected for the analysis of HIV-1 infection ... -
Measurement of improvement achieved by participation in international laboratory accreditation in sub-Saharan Africa: the Aga Khan University Hospital Nairobi experience
(Oxford University Press, 2014-02-02)As part of the ISO 15189:2007 accreditation process, the Aga Khan University Hospital Nairobi laboratory became the first internationally accredited hospital laboratory in sub-Saharan Africa outside South Africa in 2011 ... -
Family history as a risk for early-onset type 2 diabetes in Kenyan patients.
(EBSCO Industries, Inc, 2014)Early-onset type 2 diabetes is regarded as disease occurring before the age of 40 years. It is well described, and increasing in prevalence, but there is little information from Africa. We therefore assessed the prevalence ... -
Prevalence of transmitted drug resistance mutations in HIV-1-infected drug-naive patients from urban and suburban regions of Kenya
(Mary Ann Liebert, Inc., 2016-03-01)HIV was first described in Kenya in 1984–1985. Currently, Kenya has an estimated HIV-1 prevalence of 6.2%. With the introduction of antiretroviral drugs, the survival of most HIV patients has been prolonged markedly. ... -
Comparison of equations for estimating glomerular filtration rate in screening for chronic kidney disease in asymptomatic black Africans: a cross sectional study
(BioMed Central, 2017-12)Several equations have been developed to estimate glomerular filtration rate (eGFR). The common equations used were derived from populations predominantly comprised of Caucasians with chronic kidney disease (CKD). Some of ... -
Metabolic syndrome and its predictors in an urban population in Kenya: a cross sectional study
(BioMed Central, 2017-12-01)The metabolic syndrome (MetS) is a clustering of interrelated risk factors which doubles the risk of cardio-vascular disease (CVD) in 5–10 years and increases the risk of type 2 diabetes 5 fold. The identification of ... -
Complete blood count reference intervals from a healthy adult urban population in Kenya
(Public Library of Science, 2018-06-07)There are racial, ethnic and geographical differences in complete blood count (CBC) blood count (CBC) and therefore it is necessary to establish RIs that are population specific. Several studies have been carried out in ... -
Vitamin D status in healthy black African adults at a tertiary hospital in Nairobi, Kenya: a cross sectional study
(BioMed Central, 2018-12-01)Vitamin D has been known since the twentieth Century for its benefits in bone health. Recent observational studies have demonstrated its benefits in infectious diseases such as tuberculosis and non-communicable diseases ... -
Determination of reference intervals for common chemistry and immunoassay tests for Kenyan adults based on an internationally harmonized protocol and up-to-date statistical methods
(Public Library of Science, 2020-07-09)Due to a lack of reliable reference intervals (RIs) for Kenya, we set out to determine RIs for 40 common chemistry and immunoassay tests as part of the IFCC global RI project. -
A study of haemorrhoids as seen at the Kenyatta National Hospital with special reference to asymptomatic haemorrhoids.
(University of Nairobi, 1987)Haemorrhoids is a condition defined as a swelling at the anal margin, a pile. This condition has been known to afflict mankind for a long time having been documented from the time of Hipprocrates. So far it has not been ... -
Anaemia in elderly patients at Kenyatta National Hospital
(University of Nairobi, 1988)The main objective of this work was to study anaemia in elderly patients and hence contribute some baseline data for future possible work in this area. This prospective study covered 63 elderly patients of all types of ... -
Surgery of the oesophagus: a Nairobi experience.
(East African medical journal, 1993-05-01)On average, for every 100 patients with malignant dysphagia admitted into the Kenyatta National Hospital (KNH) in Nairobi, 28 will have their tumour resected. Seven in the tumour resected group will die during the postoperative ... -
Fibrosarcoma of the lung with extrapulmonary manifestations
(East African Medical Journal,, 1995-07-01)A 50-year-old female presented with a five months history of recurrent attacks of dizziness, sweatiness, tremors and fainting with loss of consciousness. These were found to be due to hypoglycaemic episodes with blood ... -
Epstein‐Barr virus in Hodgkin's disease: frequency of a 30‐bp deletion in the latent membrane protein (LMP‐1) oncogene in South African patients
(John Wiley & Sons, Inc., 1999-08-20)In recent years, substantial evidence has accumulated implicating Epstein-Barr virus (EBV) in the pathogenesis of Hodgkin’s disease (HD) and some non-Hodgkin’s lymphomas (Pallesen et al., 1993; Weiss et al., 1989). It has ... -
Paediatric rhabdomyosarcoma: MyoD1 demonstration in routinely processed tissue sections using wet heat pretreatment (pressure cooking) for antigen retrieval.
(Journal of clinical pathology, 1997-01-01)AIMS: To investigate wet heat pretreatment (pressure cooking) as a means of antigen retrieval for demonstration of MyoD1 in paraffin wax embedded tissue. METHODS: Routinely processed tissue sections of transmission electron ... -
Pregnancy in open heart surgical patients at Kenyatta National Hospital.
(East African medical journal, 1999-01-01)In the past, the Kenyatta National Hospital heart unit policy has been to discourage pregnancy among patients following open heart surgery for valve replacement, in view of the adverse effects of warfarin. OBJECTIVE: To ... -
Follow up of patients after open heart surgery.
(East African medical journal, 1998-12)To determine the patient drop out to postoperative follow up for heart patients at the Kenyatta National Hospital. DESIGN SETTING AND PARTICIPANTS: The study analysed the postoperative attendance of heart patients to the ...